The Nielsen Rating's Top 20 TV Shows for September 28 - October 4. The first number is the ranking, the second number is the season average, then the show name and network. The last number represents the number of viewers in millions. An asterisk * indicates a tie.
| Rank | Season average | Show name | Network | Viewers in millions | |
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| 1. | 1 | NCIS | CBS | 21.4 | |
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| 2. | 2 | NFL: Chargers/Steelers | NBC | 18.4 | |
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| 3. | 3 | NCIS: Los Angeles | CBS | 17.4 | |
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| 4. | 4 | Dancing with the Stars | ABC | 17.0 | |
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| 5. | 8 | CSI | CBS | 15.9 | |
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| 6. | 9 | The Mentalist | CBS | 15.8 | |
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| 7. | 5 | Grey's Anatomy | ABC | 15.7 | |
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| 8. | 6 | House | Fox | 14.7 | |
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| 9. | 12 | Desperate Housewives | ABC | 14.6 | |
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| 10. | 11 | Criminal Minds | CBS | 14.2 | |
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| 11. | 12 | CSI: Miami | CBS | 14.0 | |
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| 12. | 16 | Two and a Half Men | CBS | 13.9 | |
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| 13. | 16 | The Good Wife | CBS | 13.7 | |
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| 14. | 12 | 60 Minutes | CBS | 13.4 | |
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| 15. | 18 | Big Bang Theory | CBS | 13.3 | |
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| 16. | 12 | CSI: NY | CBS | 13.2 | |
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| 17. | 18 | Dancing with the Stars Results | ABC | 13.0 | |
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| 18. | 20 | The OT | Fox | 12.0 | |
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| 19. | 26 | Extreme Makeover: Home Edition | ABC | 11.6 | |
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| * | | Private Practice | ABC | 11.6 | |
